GalNAc, N-acetylgalactosamine is an amino sugar derivative of galactose. In the human body, GalNAc is required for intercellular communication and is concentrated in sensory nerve structures. Derivatives of GalNAc are used for a variety of applications including as oligonucleotide-based therapeutics and RNAi therapeutics by acting as a targeting ligand for the treatment of a wide variety of diseases (e.g. liver, problems, cancer, Parkinson’s Disease)1,2. We have a strong reputation for supplying high quality lipids with our nearly 40 years of experience. Now you can obtain your GalNAc starting materials from us and utilize our lipid synthesis capabilities to design and prepare custom GalNAc derivatives for your unique project needs. GalNAc derivatives can be used to conjugate to your SiRNA or oligonucleotide to enhance your drug delivery. GalNAc-siRNA conjugates have invigorated research into non-viral-based delivery systems. Our high quality GalNAc derivatives are essential in successfully achieving delivery of SiRNA and testing your systems. Our team of experienced, knowledgeable scientists are committed to your needs and provide the communication and skill required for efficient, quality synthesis. We have a reputation for supplying high-quality lipids (for Research Use Only). Now you can obtain your GalNAc starting materials from us. Use them to conjugate to your siRNA or oligonucleotide to enhance your drug delivery.
You need the confidence that you have the best quality GalNAc for your project. With Organix’ GalNAc intermediates, you are starting your research with the best chance of success. We will have an ever expanding choice of derivatives to choose from. We can provide other custom GalNAc derivatives, please call us or email sales@organixinc.com
GALNAC-BASED SIRNA DELIVERY
Synthetic siRNA can form the basis of novel therapies, these active therapeutics can be delivered to the system using novel GalNAc dendrimers. (Nature Reviews, Genetics, 271, 23, 2022) GalNAc-based formulations of these biopharmaceuticals may provide better specificity for increased immune response and possible dose reduction.
HIGH-QUALITY GALNAC INTERMEDIATES.
GalNAc-siRNA conjugates has invigorated research into non-viral-based delivery systems. High quality GalNAc derivates from Organix are essential in successfully achieving delivery of siRNA and testing your proof of concept. Call now for a custom synthesis quote or order one of our GalNAc intermediates for your research.
For Research Use Only. Sold under the Hatch-Waxman exemption (safe harbor exemption)
