Tailored RNA Therapy Solutions

Enhance siRNA Therapeutics with GalNAc

Unlock the potential of N-acetylgalactosamine (GalNAc), a multivalent targeting cluster for siRNA therapeutics and oligonucleotides that binds to the asialoglycoprotein receptor on hepatocytes. GalNAc has been shown to overcome limitations in lipid nanoparticle (LNP) efficacy due to increased polyethylene glycol (PEG) shielding (Kumar et al., 2014) allowing for more robust small molecule oligonucleotide and RNA interference (RNAi) based therapies.

Why Choose GalNAc?

Synthetic siRNA and other kinds of oligo synthesis represent a breakthrough in novel therapies, and GalNAc architectural motifs such as dendrimers (aka arborols and cascade molecules), offer a promising avenue for delivering these therapeutic agents effectively to cellular targets. GalNAc-based formulations can enhance specificity, boost immune responses, and potentially reduce required dosages, as highlighted in a recent study (Nature Reviews, Genetics, 271, 23, 2022).

Custom GalNAc Solutions

GalNAc-siRNA conjugates have revolutionized non-viral delivery systems, driving success in clinical trials and breakthroughs in therapeutic research for diseases including liver disorders, cancer, and neurodegenerative conditions like Parkinson's Disease. With Organix, you can access a wide range of premium GalNAc starting materials and leverage our lipid and oligonucleotide synthesis expertise to design bespoke GalNAc systems and chemical structures and chemical modification tailored to your project's unique requirements.

Why Choose Organix?

At Organix, we bring nearly 40 years of experience to the table, making us your trusted source for high-quality PEG lipid conjugates and GalNAc conjugates including phospholipid-GalNAc conjugates and negatively charged O-GalNAc glycans. GalNAc derivatives serve as essential tools for enhancing oligonucleotide drug delivery vaccine lipid including lipid-based vaccines, our other products in this area include lipid nanoparticles (LNPs).

Wide Range of GalNAc Intermediates

Confidence in your research begins with the best-quality and highest purity intermediates. Organix offers a continually expanding selection of GalNAc derivatives and phosphorothioate oligonucleotides, giving you the flexibility to choose the right components for your gene silencing projects, from small interfering RNA (siRNA) to antisense oligonucleotides (ASOs). For additional custom intermediates, reach out to us via phone or email at sales@organixinc.com.

Beside our wide range of products, we are also known for:

• Quality Assurance: We are renowned for supplying high-quality lipids (for Research Use Only, ask us about our GMP grade lipids), ensuring that your experiments are built on a solid foundation of excellence.

• Experienced Team: Our team of experienced scientists is dedicated to meeting your needs, providing the expertise, communication, and skill necessary for efficient and top-notch synthesis and lipid analysis.

For Research Use Only. Sold under the Hatch-Waxman exemption (Safe Harbor Exemption).

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