Medicinal Chemistry
Services

 

Driving Drug Discovery and Development

Our medicinal chemistry expertise enables breakthroughs in pharmaceutical innovation:

Hit-to-lead optimization & SAR studies for rapid discovery cycles.

Parallel synthesis & computational chemistry to streamline workflows.

Early ADME services (via our sister company ADMEscope) to enhance compound profiling.

From RNA interference to impurity profiling, our medicinal chemistry CRO services provide comprehensive support for biotherapeutics. Our lipids used in lipid nanoparticles (LNPs) and our polymers used in polymer nanoparticles (PNPs) are highly regarded ingredients used in vaccine research, gene therapy and drug delivery.

  • CASE STUDY #1

    A young biotech company engaged Organix to design an SAR (Structure Activity Relationship) study focused
    on the discovery of compounds which target a unique biological receptor. Organix implemented a 2-year synthesis program in which over 175 compounds involving 5-8 synthetic steps and over 450 compounds involving 2-5 steps
    were prepared and evaluated. The lead compound that emerged from the biological studies was scaled up at Organix to 100 g. Thus far, two patents have been filed on these compounds.

  • CASE STUDY #2

    A multinational pharmaceutical company has engaged Organix services for over 25 years. These services have included basic research and custom synthesis projects. Over this period Organix has assigned between 1-3 FTEs to a very broad array of projects. Organix has been involved in the design of new synthetic routes and the preparation on milligram
    to gram scale of novel analogs of lead compounds from the client company’s research program. In addition, many key intermediates have been provided on multigram scale. As example, in 1 year, 40 fully characterized final compounds,
    each of which required 4-10 synthetic steps were provided.

  • CASE STUDY #3

    This client engaged Organix services at the level of 3-4 FTEs for one year until its purchase by a large multinational pharmaceutical company. Organix designed synthetic routes to selected compounds.
    In most instances, routes to these compounds were not reported in the literature, or were inadequate for scale-up.
    During the period of this work, 43 compounds that required 5-11 synthetic steps were provided in 1–15 g quantities;
    7 compounds requiring 4 – 8 steps were provided in 40–400 g quantities, and 50 compounds that required 6-8 steps
    per compound were provided for SAR studies in 20–50 mg quantities.

  • CASE STUDY #4

    A multinational client engaged Organix services in support of a medicinal chemistry program. While Organix designed the synthetic routes and suggested compounds, the client chose to keep all medicinal chemistry aspects confidential. Over the period of this contract, 2 FTEs produced 100 compounds a year. These compounds ranged from 2 steps procedures to 18 steps and were provided in 100 mg to 10 g quantities.

Advancing Drug Delivery with Medicinal Chemistry

Organix has a long-standing legacy in medicinal chemistry for drug delivery, including expertise in:

GalNAc Conjugation: Coupling small molecules and lipids to GalNAc dendrimers for targeted delivery.

Bioconjugates: Applying advanced synthesis techniques to conjugate small or large molecules to proteins (such as HRP) and synthetic polymers (such as HPMA polymers).

Controlled Substance Synthesis: Organix has the expertise and is fully licensed to synthesize controlled substances (Schedules I through IV).

Purification & Characterization: Expertise in normal and reverse-phase chromatography for purification and NMR techniques for structural characterization of all organic molecules. Our multinuclear NMR allows advanced 2D-NMR techniques such as proton observed 15N-NMR.

We work closely with you to solve your most challenging synthesis and formulation problems, ensuring high-quality, scalable solutions for your drug delivery needs.

Symegold Library

Organix provides access to Symeres’ Symegold library, a collection of more than 75,000 novel and lead-like compounds for high-throughput screening (HTS). This library of derivatized scaffolds has been carefully designed to cover as much druglike space as possible, whilst maintaining favorable physicochemical properties. Furthermore, the library design principles allow for the expedient synthesis of additional analogues and scaffold hopping can be employed to quickly expand the chemical diversity.

Explore Our Services

Medicinal
Chemistry

Drug Delivery
Solutions

Custom
Synthesis

Analytical
Services

Polymer
Chemistry

Process
Development