Medicinal Chemistry
Organix has been involved in lipid synthesis since Organix was founded in 1986.
During this time we have been involved in proprietary synthesis of novel lipids as well as synthesis of standards from the published literature.
LIPIDS/LIPOIDS FOR mRNA DELIVERY
HIT TO LEAD AND SAR STUDIES
POLYMER CONJUGATES, BIOCONJUGATES, & OLIGONUCLEOTIDES
natural products
MICROSPHERE SYNTHESIS & MICROENCAPSULATION
Controlled substances
LIPIDS/LIPOIDS FOR mRNA DELIVERY
WE HAVE IN-DEPTH EXPERIENCE IN the synthesis and purification of lipids:
At Organix, we offer a wide variety of custom synthesis capabilities. Our custom synthesis of lipids is one of our areas of expertise. Organix has nearly 40 years of experience in the synthesis, purification and handling, and analysis of lipid compounds. We have a strong reputation for producing and supplying high-quality lipids for research applications. With partnerships with biotech, pharma, academic, and government industries, we have a track record of satisfied clientele. We are also made up of a team of over 40 Ph. D. scientists with the knowledge and skill to provide you with quality products in an efficient manner. Our lipid synthesis capabilities include a broad range of specialty lipids such as MC3, the gold standard of ionizable lipids, cationic lipids, lipopeptides, lipoids, biodegradable lipids, arachidonyl lipids, GalNAc derivatives, lipid scaleup, and microspheres. To learn more about our custom lipid synthesis and what is offered, please visit our specialty lipids section.
Organix understands purity is of utmost importance when it comes to lipids for drug delivery and nano-particle formation. Therefore our lipids are of the highest purity and we use only the most reputable of suppliers for our starting materials in any of our lipid/lipoid synthesis.
We are now proud to offer GMP lipid synthesis capabilities for our clients.
HIT TO LEAD AND SAR STUDIES
We provide quality services in medicinal chemistry and synthetic chemistry:
When a project is long-term, complex, or involves new ideas and strategies, a strong team of scientists with knowledge and determination is the key to success. Our synthetic chemistry FTE collaborations offer skilled Ph.D. scientists who dedicate their full efforts at the bench to your needs. Whether it is designing or readapting synthetic pathways or the need for flexibility to change goals and priorities on an immediate basis, we have got you covered. With full dedication to FTE projects, our scientists can problem solve, and trouble shoot any issues that may arise to keep progress moving on projects. Organix has renovated and revamped our facilities for quicker, better analyses of compounds where our teams have little to no wait time for analysis to keep projects running smoothly. Comprehensive, effective communication with our clients is a hallmark of our successful collaborations. FTE costs include supervision and management by an Organix manager, regular communications (face to face or video conference), written progress reports, consultation with Organix’ Manager of Analytical Services. FTE projects are generally invoiced on a monthly basis at a set FTE rate and no project is too small or too large.
Organix was acquired by Symeres (headquartered in the Netherlands) in April 2022. By joining the Symeres family, this started an exciting new chapter for our company. With our partnership, we can expand our services to offer exciting and new chemistry! Symeres is the leading mid-sized transatlantic contract research organization for your drug discovery and development challenges. Symeres is made up of over 600 expert scientists across six locations in Europe and two in the USA. For over 30 years they have offered quality solutions for drug discovery and drug development, from small to medium-sized molecule hits. Services span across early stage hit findings to delivery of early clinical drug substance API. To learn more, check out Symeres and what they have to offer!
POLYMER CONJUGATES, BIOCONJUGATES, & OLIGONUCLEOTIDES
HRP CONJUGATEs
Organix designs and synthesizes small molecules containing selected linkers for attachment to HRP. These conjugates are purified (TFF) and characterized (NMR & HPLC-UV/HPLC-ELSD). These conjugates incorporate derivatives of steroids (e.g.progesterone, cortisol, estradiol) and indole analogs (e.g.melatonin).
Organix synthesizes polymer conjugates containing stable isotope labels. Loading ratios are determined. (Annal. Chem. 2002, 74, 4969)
THIOL REACTIVE CONJUGATES
Organix prepares PEG-dye polymer conjugates. These are purified (TFF and C18-RP chromatography) and characterized (NMR & HPLC) (Nature Biotech 2008, 26(2), 235)
Organix designs and synthesizes PEG–vitamin derivatives. Linked compounds are regio-selectively attached to bifunctional PEG compounds. Conjugates are purified (HPLC) and characterized (NMR). Conjugates are linked to proteins and antibodies.
PEG CONJUGATES
Organix prepares HPMA polymer conjugates (RAFT polymerization / living polymers.) Conjugates are purified (TFF and C18-RP chromatography) and characterized (NMR) and analyzed (HPLC/GPC).
HPMA CONJUGATES
Organix has coupled small molecules and lipids to GalNAc. Purification (reverse phase chromatography) and characterization (NMR) on these conjugates (MW >1,500-4,000) is conducted.
GaLNAC CONJUGATES
Organix conducts phosphitylation. These building blocks are synthesized, purified and characterized (NMR & HPLC-UV/HPLC-ELSD).
PHOSPHITYLATION
NATURAL PRODUCTS
Organix has considerable experience in the extraction/isolation/identification of compounds from Natural Resources. The following selection of case studies exemplify our experience.
Case Study #1: Biological Active was unknown from plant leaves.
In this case the client came to Organix with biological results of a natural product derived from plant leaves. The structure of the active compound was unknown and the occurrence (% of active/biomass) was also undetermined. Organix was provided 1 kg of leaves which we processed by first converting to a fine powder (blender) and then we subjected the powder to extraction with various solvents of different polarity. We also treated the powder with water: basic, neutral and acidic. Each of the fractions were then sent to the client for biological testing and then the active was followed until chromatography was needed and eventually, we ended up with pure material. This organic pure material was the active component and we were able to identify the material by MS and 2D NMR. A literature search eventually led to us finding a publication of the exact compound that had been synthesized a year earlier by a well-known professor.
Case Study #2: Biological Active was known and an isolation protocol requested.
In this case the client already knew the active compound and the plant genus and we obtained different plants from different regions of the country/globe and investigated the occurrence of the active in different parts of the plant. We then went on to develop a high yielding method of extraction and isolation of the active and confirmed the identity by LCMS & NMR as compared with an authentic sample.
Case Study #3: SAR Program from a natural product extracted from an oil.
In this case the client provided a large amount of oil that contained an enriched mixture of four related natural products. Organix conducted a multiyear multiple FTE program where we isolated the natural products and made analogs of the four classes and sent them for biological testing. This was a long-term project with a major pharmaceutical company with weekly meetings. Our SAR was directed by the biological results and derivatives were synthesized in order to enhance the physical properties of the compounds as well as increase their efficacy and biological activity.
MICROSPHERE SYNTHESIS & MICROENCAPSULATION
Microspheres are small spherical particles with micrometer diameters that are typically 1 µm to 1000 µm and possessing no membrane or distinct outer layer. Composed of a variety of different materials (glass, polymer, metal, and ceramic), microspheres are used for a variety of applications. Applications of microspheres include, but are not limited to, the composite industry (e.g. oil and gas, paints and coating), cosmetic and personal care industry (e.g. exfoliating agents, anti-aging), medicine (e.g. reagents of diagnostic devices, injectable biomaterial), life sciences (e.g. fluorescent labels for detection, microfluids), and specialized industries (e.g. soil and marine life, filtration systems and membranes).1 Organix has considerable experience with the microencapsulation of a variety of drugs. Our expertise includes the preparation of gels and other inert polymeric coatings for chemotherapeutic agents, opioids for pain management, and other pharmaceutical agents where controlled release via biodegradation is desired. We optimize experimental conditions to vary the size and loading of the microspheres obtained and carry out time release studies at ambient and elevated temperatures. Stability studies and evaluation of drug half lives are conducted also. Here at Organix, our team of expert scientists have in-depth experience in the synthesis of microspheres, purification of microspheres, and analysis of microspheres.
CONTROLLED SUBSTANCES
Organix is DEA-licensed for research and manufacturing of controlled substances and their derivatives or analogs in Schedules I through IV. We offer reference standards in the following areas: opioids, tropanes, and tryptamines. Additionally, we also have extensive research experience in these specialized templates. If this is of interest to you and your project needs, please contact us. With our extensive experience, we value your goals and provide you with quality products and research.