A young biotech company engaged Organix to design an SAR (Structure Activity Relationship) study focused
on the discovery of compounds which target a unique biological receptor. Organix implemented a 2-year synthesis program in which over 175 compounds involving 5-8 synthetic steps and over 450 compounds involving 2-5 steps
were prepared and evaluated. The lead compound that emerged from the biological studies was scaled up at Organix to 100 g. Thus far, two patents have been filed on these compounds.

A multinational pharmaceutical company has engaged Organix services for over 25 years. These services have included basic research and custom synthesis projects. Over this period Organix has assigned between 1-3 FTEs to a very broad array of projects. Organix has been involved in the design of new synthetic routes and the preparation on milligram
to gram scale of novel analogs of lead compounds from the client company’s research program. In addition, many key intermediates have been provided on multigram scale. As example, in 1 year, 40 fully characterized final compounds,
each of which required 4-10 synthetic steps were provided.

This client engaged Organix services at the level of 3-4 FTEs for one year until its purchase by a large multinational pharmaceutical company. Organix designed synthetic routes to selected compounds.
In most instances, routes to these compounds were not reported in the literature, or were inadequate for scale-up.
During the period of this work, 43 compounds that required 5-11 synthetic steps were provided in 1–15 g quantities;
7 compounds requiring 4 – 8 steps were provided in 40–400 g quantities, and 50 compounds that required 6-8 steps
per compound were provided for SAR studies in 20–50 mg quantities.

A multinational client engaged Organix services in support of a medicinal chemistry program. While Organix designed the synthetic routes and suggested compounds, the client chose to keep all medicinal chemistry aspects confidential. Over the period of this contract, 2 FTEs produced 100 compounds a year. These compounds ranged from 2 steps procedures to 18 steps and were provided in 100 mg to 10 g quantities.