Organix has been involved in lipid synthesis since Organix was founded in 1986.

During this time we have been involved in proprietary synthesis of novel lipids as well as synthesis of standards from the published literature.

LIPIDS/LIPOIDS FOR mRNA DELIVERY

HIT TO LEAD AND SAR STUDIES

POLYMER CONJUGATES, BIOCONJUGATES, & OLIGONUCLEOTIDES

cannabinoid synthesis

natural products

MICROSPHERE SYNTHESIS & MICROENCAPSULATION

Controlled substances

HRP CONJUGATEs

Organix designs and synthesizes small molecules containing selected linkers for attachment to HRP. These conjugates are purified (TFF) and characterized (NMR & HPLC-UV/HPLC-ELSD). These conjugates incorporate derivatives of steroids (e.g.progesterone, cortisol, estradiol) and indole analogs (e.g.melatonin).

Case Study #1: Biological Active was unknown from plant leaves.

In this case the client came to Organix with biological results of a natural product derived from plant leaves. The structure of the active compound was unknown and the occurrence (% of active/biomass) was also undetermined. Organix was provided 1 kg of leaves which we processed by first converting to a fine powder (blender) and then we subjected the powder to extraction with various solvents of different polarity. We also treated the powder with water: basic, neutral and acidic. Each of the fractions were then sent to the client for biological testing and then the active was followed until chromatography was needed and eventually, we ended up with pure material. This organic pure material was the active component and we were able to identify the material by MS and 2D NMR. A literature search eventually led to us finding a publication of the exact compound that had been synthesized a year earlier by a well-known professor.

Case Study #2: Biological Active was known and an isolation protocol requested.

In this case the client already knew the active compound and the plant genus and we obtained different plants from different regions of the country/globe and investigated the occurrence of the active in different parts of the plant. We then went on to develop a high yielding method of extraction and isolation of the active and confirmed the identity by LCMS & NMR as compared with an authentic sample. 

Case Study #3: SAR Program from a natural product extracted from an oil.

In this case the client provided a large amount of oil that contained an enriched mixture of four related natural products. Organix conducted a multiyear multiple FTE program where we isolated the natural products and made analogs of the four classes and sent them for biological testing. This was a long-term project with a major pharmaceutical company with weekly meetings. Our SAR was directed by the biological results and derivatives were synthesized in order to enhance the physical properties of the compounds as well as increase their efficacy and biological activity.