A Viable Alternative to Lipid Nanoparticles
At Organix, we're excited to introduce the groundbreaking potential of polymer nanoparticles (PNPs) as an alternative to lipid nanoparticles for mRNA encapsulation. These dynamic particles serve the same vital role as drug delivery systems in nanotechnology, but with possibly lower toxicity and less potential for accumulation in the liver. Our expertise in polymers for use in polymer nanoparticles (PNP) underpins our purification and characterization services, employing polymer characterization techniques such as Tangential Flow Chromatography (TFF), Gel Permeation Chromatography (GPC), and Size Exclusion Chromatography (SEC) to deliver pure, high quality results. Now available GMP grade also.
Special Focus on RAFT Polymerization Techniques
RAFT or Reversible Addition–Fragmentation chain Transfer allows the synthesis of macromolecules with complex architectures and allows to dial in the desired Mw. We use RAFT polymerization for a range of monomers, including the preparation of water-soluble materials.
Work with Us
Our Methods
TFF: an advanced water-soluble polymer purification technique, provides a viable alternative to size exclusion spin chromatography. It excels in purifying water soluble polymers and can also be applied for desalting proteins, or purifying bio-polymer conjugates such as HRP conjugates.
Effective Drying Methods and the careful use of fresh, anhydrous solvents are crucial to prevent bimodal distribution. Monomers and low molecular weight polymers can be removed through meticulous precipitation or TFF.
GPC: a potent chromatographic technique, is a key tool for product characterization. Its ability to detect varying molecular weight polymers and trace monomer contamination in crude polymers provides valuable insights for informed preclinical testing.
Characterization: is crucial in our work. By identifying aspects like molecular weight distribution (Mw, Mz, Mp, Mn) and polydispersity (PDI), we offer a comprehensive understanding of the polymer under study.
Polymer Nanomedicine Innovations
At Organix, we are passionate pioneers in the exciting and still largely unexplored field of novel polymer development. We do not directly manufacture nanoparticles, but specialize in producing the essential building blocks for the formation of polymer nanoparticles used in encapsulation of mRNA and single-strand-interfering DNA (ssDNA).
Our expertise in radical polymerization extends to the polymerization of N-(2-hydroxypropyl)methacrylamide (HPMA) conjugates and the utilization of various initiators and chain transfer agents allowing a complete gamut of reversible addition−fragmentation chain-transfer (RAFT polymerization.)
Drug Delivery Polymer Solutions
Polymer characterization is integral to understanding to understanding the advancements in drug delivery innovations and polymer nanomedicine innovations. The applications of polymer-based nanoparticles for smart drug delivery highlight the intersection of Nanomedicine Advancements and the practical utilization of polymer nanoparticle applications. These developments collectively contribute to the evolving landscape of innovative drug delivery strategies in the field. Now available GMP grade also.
Why Choose Organix
At Organix, our team of passionate PhDs and technical organic chemists brings a wealth of expertise and a unique edge to our synthetic approach. With extensive experience in polymer chemistry, including monomers and conjugated polymer nanoparticles, we uniquely understand the specific needs of medical medicinal chemists, biologists, and other professionals focused on practical applications.
Our commitment to excellence, innovation, and collaboration enables us to deliver cutting-edge solutions tailored to the needs of our clients. At Organix, we are not just providers – we are dedicated partners in success, prioritizing purity, quality, and fostering strong relationships to propel our clients forward in the biotech, pharmaceutical, and research industries. Join us on this exciting journey towards pharmaceutical polymer research.