Custom Polymer Synthesis
Custom Synthesis of Polymers Using Raft Agents
We custom synthesize the molecules using RAFT polymerization techniques that allow us to produce different molecular weight ranges for the polymers. Polymers can be purified using Tangential Flow Filtration (TFF, for water soluble polymers) or Reverse Phase Chromatography for non-water soluble polymers. These polymers can be conjugated or the monomer synthesized with the drug-like molecule attached for use in the polymerization reaction. Polymer characteristics (such as Mw, Mn, Mz, Mp and PDI) can be determined using Gel Permeation Chromatography (GPC).
Why Use RAFT Agents?
RAFT or Reversible Addition–Fragmentation chain Transfer allows the synthesis of macromolecules with complex architectures and allows to dial in the desired Mw. We use RAFT polymerization for a range of monomers, including the preparation of water-soluble materials.