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Peter C. Meltzer
President & CEO of Organix Inc.

BIOGRAPHICAL SKETCH
EDUCATION

Institution Degree Year Conferred Field of Study
       
Univ. of the Witwatersrand, S. Afr. B.Sc. (Hons.) 1972 Chemistry
Univ. of the Witwatersrand, S. Afr. Ph.D. 1976 Organic Chemistry
Massachusetts Institute of Technology Post-doc 1977 Organic Chemistry

Research and Professional Experience

1971 - 1976 Lecturer and Teaching Assistant, Univ. of the Witwatersrand.
1976 - 1977 Research Associate, Univ. of the Witwatersrand, Johannesburg.
1977 - 1978 Research Associate, Massachusetts Institute of Technology.
1978 - 1983 Group Leader, Senior Chemist, Research Associate, SISA Inc.
1983 - 1986 Vice President of Research and Development, Director of Chemistry, SISA Inc., Cambridge, Massachusetts
1986 - President & CEO, Co-founder and member of the Board of Directors of Organix Inc., Massachusetts Research and Development Company

Awards

1968 - 1971 Johannesburg City Council Scholarship.
1972 Senior Bursar of the University of the Witwatersrand.
1972 South African. Council for Scientific and Industrial Research Scholarship.
1975 University of the Witwatersrand Senate Research Grant.

Professional Activities

1977 - Member, American Chemical Society.
1983 - 1986 Associate Editor, The Nucleus, Northeastern Section of the American Chemical Society (NESACS)
1983 Medicinal Chemistry Group, NESACS.
1983 Chairman, ACS Symposium: "The Pharmaceutical Industry to the Turn of the Century", Boston College, Newton, MA.
1984 Chairman, ACS Symposium: "Chemistry and Immunology," Arthur D. Little Inc., Cambridge MA.
1984, 1985 Chairman, Medicinal Chemistry Group, NESACS.
1987/9 Member, Nominating Committee, NESACS
1990 Member, Long Range Planning Committee, NESACS
1991 - Member, Society for Neuroscience
1993 - Member, College on Problems of Drug Dependence
2010 - 2013 Trustee of the Northeastern Section of the American Chemical Society

Consultant

NIH, Med. Chem. Study Section (AHR)

NICHD, Study Section (AHR)

Publications

  • "Nuclear Bromination of 2',5'-Dimethylbenzoylacetanilide," P. C. Meltzer and B. Staskun, J. of the S. Afr. Chem. Inst., 3, 119, 1974.
  • "The Role of Nuclear Halogen in the Cyclization of Benzoylacetanildes to Indeno (1,2,3-de) quinolinones," B. Staskun and P. C. Meltzer, Tetrahedron, 33, 2965, 1977.
  • "The Mechanism of Indeno (1,2,3-de) quinolinone Formation," P. C. Meltzer and B. Staskun, J. Org Chem.,42, 2977, 1977.
  • "Double Migration of Methyl and Bromine Accompany Indeno(1,2,3-de) quinolinone Formation," P. C. Meltzer and B. Staskun, Tetrahedron,33, 2965, 1977.
  • "Intramolecular Migration Accompanying Indeno (1,2,3-de) quinolinone Formation," P.C. Meltzer and B. Staskun. Proceedings of the South African Chemical Institute, 1973.
  • "The Mechanism of Indeno (1,2,3-de) quinolinone Formation and an Unambiguous Synthesis of an Important Indenoquinolinone," P. C. Meltzer and B. Staskun, Proceedings of the South African Chemical Institute , 1975.
  • "Drugs Derived from Cannabinoids 8. The Synthesis of Side Chain Analogues of 6a,10a-Tetrahydrocannabinol," P. C. Meltzer, H. C. Dalzell and R. K. Razdan, J. Chem. Soc., 11, 2825, 1981.
  • "An Improved Synthesis of Cannabinol and Cannabiorcol," P. C. Meltzer, H.C. Dalzell and R.K. Razdan, Synthesis,12, 985, 1981.
  • "Relative Protective Effects of 20 Homologs of 4-(2-Bromo- 4,5-dimethoxyphenyl)-octahydro-2H-quinolizin-2-one (JB-1-0) Against Croton Oil Induced Inflammation in Mice," H.H. Malone, J. Quick and P. C. Meltzer, Proc. West. Pharmacol. Soc.,26, 351,1983.
  • "Synthetic Studies on the Lythraceae Alkaloids XI. Model Studies for the Synthesis of Lythrancine V," J. Quick, Y. Khandelwal, P. C. Meltzer and J.S. Weinberg, J. Org. Chem., 48, 5199, 1983.
  • "Evaluation of Four Homologs of 4-(2-Bromo-4,5-dimethoxyphenyl)- octahydro- 2H-quinolizin-2-one (JB-1-0) for their Capacity to Prevent Carrageenan induced Pedal Edema in the Rat," J.A. Byrne, M.H. Malone, J. Quick and P. C. Meltzer, Proc. West. Pharmacol. Soc., 27, 293, 1984.
  • "Ring Closure of Thiosemicarbazides-A Structure Correction," H.Sard, P. C. Meltzer, R. K. Razdan, J. Het. Chem.,22, 361, 1985.
  • "The Reaction Between an Azomethine and Malonyl Dichloride," H. Sard, P. C. Meltzer and R. K. Razdan, J. Het. Chem.,22, 257, 1985.
  • "A Regioselective Route to Gossypol Analogs: The Synthesis of Gossypol and 5,5'-Didesisopropyl-5,5'-diethyl Gossypol," P. C. Meltzer, P. H. Bickford and G. Lambert, J. Org. Chem., 50, 3121, 1985.
  • "Analgesic and Narcotic Antagonist Activity of Synthetic Cannabinoids," H.G. Pars, R. K. Razdan, L. S. Harris, W. L. Dewey, E. M. Essigmann, P. C. Meltzer and A. Cowan, ASPET-ACSDMC Meeting, Boston, 1985.
  • "Ultrastructural, Fertility, and Spermicidal Studies with Isomers and Deivatives of Gossypol in Male Hamsters", A. P. Hoffer, A. Agarwal, P. C. Meltzer, P. Herlihy, R. H. Naqvi, M. C. Lindberg, and S. A. Matlin, Biology of Reproduction, 37, 909, 1987.
  • "Antifertility, Spermicidal and Ultrastructural Effects of Gossypol and Derivatives Administered Orally and by Intratesticular Injections", A. P. Hoffer, A. Agarwal, P.C. Meltzer, R. Naqvi, and S. A. Matlin, Contraception, 37, 301, 1988.
  • "Imaging Probes for Cocaine Receptors in Human and Nonhuman Primate Brain", B. Madras, M. J. Kaufman, R. D. Spealman, M. A. Fahey, P. C. Meltzer, A. Liang, A-L. Brownell, J. Schumacher, O. Isacson, G. L. Brownell, and D. R. Elmaleh, Problems of Drug Dependence, 1991, Proc. of the 53rd Annual Scientific Meeting, CPDD.
  • "Cocaine Congeners as Probes for Cocaine Receptors and Parkinson's Disease", B. Madras, D. R. Elmaleh, P. C. Meltzer, A. Liang, G. Brownell, and A. L. Brownell, American Nuclear Society, 65, 8-9, 1992.
  • "PET Imaging Probes for the Cocaine Receptors: A Validation Study in a Nonhuman Primate Model", D. R. Elmaleh, P. C. Meltzer, B. K. Madras, A. Liang, A. L. Brownell, P. Hantraye, O. Isacson, T. Shoup, A. J. Fishman, G. L. Brownell, and H. W. Strauss, Presentation at the Society for Nuclear Medicine, 39th Annual Meeting, Los Angeles, June, 1992.
  • "Synthesis and C-11 Labeling of some 3b-Phenyltropane-2-carboxylic esters (WIN) Analogs for PET", D. R. Elmaleh, P. C. Meltzer, B. Madras, A. Liang, A. L. Brownell, P. Hantraye, O. Isacson, T. Shoup, A. J. Fishman, G. L. Brownell, and H. W. Strauss, Presentation at the International Symposium Radiopharmaceutical Chemistry, Paris, France, 1992.
  • "Halogenated Cocaine Analogs: Lack of Correlation between Ligand Binding Affinity, In Vivo Potency, and In Vivo Efficacy", David R. Compton and Peter C. Meltzer, Presentation at ASPET, Orlando, Florida, 1992.
  • "The Dopamine transporter: a target of cocaine-like drugs and a marker for Parkionson's disease", B. K. Madras, M. J. Kaufman, M.A. Fahey, S. Kish, K. Shannak, O. Hornykiewicz, P. C. Meltzer, P. Hantraye, G. L. Brownell, D. R. Elmaleh, A. L. Brownell, 7th International Catechol Symposium, 193, 1992.
  • "Substitued 3-Phenyltropane Analogs of Cocaine: Synthesis and Inhibition of Binding at the Cocaine Receptor", P. C. Meltzer, A. Liang, A. L. Brownell, D. R. Elmaleh, and B. K. Madras, J. Med. Chem., 36, 855-862, 1993.
  • "Parkinsonian Signs in MPTP-treated Monkeys are Alleviated by the High Efficacy D1 Dopamine Receptor Agonist SKF 81297", B. K. Madras, D. R. Elmaleh, P. C. Meltzer, D. E. Lee-Parritz, P. Hantraye, O. Isacson, G. L. Brownell, and A. L. Brownell, Society for Neuroscience Abstracts, #935, 18, 1992.
  • "High Affinity Probes for Cocaine Recognition Sites on the Dopamine Transporter", L. M. Gracz, B. K. Madras, R. Hanson, D. Elmaleh, P. C. Meltzer, Society for Neuroscience Abstracts, #617.6, 19, 1993.
  • "Positional Importance of the Nitrogen Atom in Novel Piperidine Analogs of GBR 12909: Affinity and Selectivity for the Dopamine Transporter", A. K. Dutta, P. C. Meltzer, and B. K. Madras, Med. Chem. Res., 3, 209-222, 1993.
  • "The Discovery of an Unusually Selective and Novel Cocaine Analog: Difluoropine. Synthesis and Inhibition of Binding at Cocaine Recognition Sites", P. C. Meltzer, A. Liang, and B. K. Madras, J. Med. Chem., 37, 2001-2010, 1994.
  • "O-526, a piperidine analog of GBR 12909, retains high affinty for the dopamine transporter in monkey caudate-putamen", B. K. Madras, M.E.A. Reith, P. C. Meltzer, and A. K Dutta, Eur. J. Pharmacol., 267, 167-173, 1994.
  • "Positron Emission Tomography of Cocaine Bonding Sites on the Dopamine Transporter", B.K. Madras, D. E. Elmaleh, P. C. Meltzer, A. Y. Liang, G. L. Brownell, and A-L. Brownell, NIDA Res. Mono., 138, 57- 68, 1994.
  • "In contrast to R-cocaine/R-cocaine analogs, novel S-analogs of benztropine are potent and selective inhibitors of the dopamine transporter: implications for cocaine binding", B. K. Madras, A. Liang, and P. C. Meltzer, CPDD, abstract 112, 1994.
  • "The Discovery of a Novel Tropane Analog which binds Potently and Selectively to the Dopamine Transporter", P. C. Meltzer, A. Liang, and B. K. Madras, CPDD, abstract 111, 1994.
  • "PET imaging of cocaine binding sites on the dopamine transporter: An application for medications development", A-L. Brownell, D. E. Elmaleh, P. C. Meltzer, and B. K. Madras, CPDD, abstract 121, 1994.
  • "In contrast to inactive S-cocaine, a novel series of S-cocaine congeners display high affinity and selectivity for the dopamine transporter", B. K. Madras, A. Liang, and P. C. Meltzer. Society for Neuroscience, abstract, 1994.
  • "Difluoropine. A highly selective cocaine analog for PET studies of dopamine transporters: Preliminary evaluation in the monkey brain", B. K. Madras, D. R. Elmaleh, P. C. Meltzer, A. Y. Liang, T. Shoup, A. J. Fischman, and A-L. Brownell, J. Nucl. Chem., 36, 117, 1995.
  • "I-123 IACFT: Radiolabeling and biodistribution in rats", J. W. Babich, P. C. Meltzer, W. Graham, D. R. Elmaleh, B. K. Madras, and A. J. Fischman, J. Nucl. Chem., 36, 145, 1995.
  • "SPECT imaging of dopamine transporter sites in normal and MPTP treated Rhesus monkeys", A. J. Fischman, J. W. Babich, D. R. Elmaleh, P. C. Meltzer, S. A. Barrow, and B. K. Madras, J. Nucl. Chem., 36, 87, 1995.
  • "Peptide Nucleic Acids: Synthesis of Thymine, Adenine, Guanine and Cytosine Nucleobases", P. C. Meltzer, A. Liang, and P. Matsudaira, J. Org. Chem, 60, 4305-4308, 1995.
  • "Altropane: A novel SPECT imaging agent for cocaine binding sites on the dopamine transporter", B. K. Madras, L. M. Gracz, M. J. Kaufman, P. C. Meltzer, D. Elmaleh, A. J. Fischman, CPDD, abstract , 1995
  • " SAR of difluoropine: A potent and selective ligand for the dopamine transporter", P. C. Meltzer, A. Y. Liang, and B. K. Madras, CPDD, abstract , 1995
  • "2-Carbomethoxy-3-(diarylmethoxy)-1aH,5aH-tropane analogs: Synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series", P. C. Meltzer, A. Y. Liang, B. K. Madras, J. Med. Chem., 39, 371-379, 1996.
  • "Technepine: A high-affinity 99mTechnetium probe to label the dopamine transporter in brain by SPECT imaging", B. K. Madras, A. G. Jones, A. Mahmood, R. E. Zimmerman, B. Garada, B. L. Holman, A. Davison, P. Blundell, P. C. Meltzer, Synapse, 22, 239-246, 1996.
  • "Design and synthesis of technepine: A 99mTechnetium probe which labels the dopamine transporter", P. C. Meltzer, P. Blundell, A. G. Jones, A. Mahmood, R. E. Zimmerman, B. Garada, B. L. Holman, A. Davison, B. K. Madras, CPDD, abstract , 1996.
  • " Nitrogen-based drugs are not essential for blockade of monoamine transporters", B. K. Madras, Z. B. Pristupa, H. B. Niznik, A. Y. Liang, P. Blundell, M. D. Gonzalez, P. C. Meltzer, Synapse, 24, 340-348, 1996.
  • "Preparation and biological evaluation of iodine-125-IACFT: A selective SPECT agent for imaging dopamine transporter sites", D. R. Elmaleh, A. J. Fischman, T. M. Shoup, B. Chang, R. N. Hanson, A. Y. Liang, P. C. Meltzer, B. K. Madras, J. Nucl. Med. 37, 1197-1202, 1996.
  • "Cocaine congeners as PET imaging probes for dopamine terminals", A-L. Brownell, D. R. Elmaleh, P. C. Meltzer, T. M. Shoup, G. L. Brownell, A. J. Fischman, B. K. Madras, J. Nucl. Med. 37, 1186-1192, 1996.
  • "Preparation and biological evaluation of iodine-125-IACFT: A selective SPECT agent for imaging dopamine transporter sites", D. R. Elmaleh, A. J. Fischman, T. M. Shoup, C. Byon, R. N. Hanson, A Y. Liang, P. C. Meltzer, B. K. Madras, J. Nucl. Med. 37, 1197-1202, 1996.
  • "SPECT imaging of dopamine transporter sites in normal and MPTP-treated rhesus monkeys", A. J. Fischman, J. W. Babich, D. R. Elmaleh, S. A Barrow, P. C. Meltzer, R. N. Hanson, B. K. Madras, J. Nucl. Med. 38, 1997, 144-150.
  • "SPECT imaging of the dopamine transporter with [123I]-2β-carbomethoxy-3β-(4-fluorophenyl)-N-(1-iodoprop-1en-3-yl)nortropane ([123I]IACFT): initial experience in humans", A. J. Fischman, A. A. Bonab, J. W. Babich, N. A. Alpert, D. R. Elmaleh, S. A Barrow, W. Graham, P. C. Meltzer, R. N. Hanson, B. K. Madras, Neuroscience-Net, 1, #00010, 1997.
  • "Synthesis of 6- or 7- hydroxy and 6- or 7- methoxy tropanes", Z. Chen, P. C. Meltzer, Tetrahedron Lett. 1997, 38, 1121-1124.
  • "A 99mTechnetium SPECT imaging agents which targets the dopamine transporter in primate brain", P. C. Meltzer, P. Blundell, A. G. Jones, A. Mahmood, B. Garada, R. E Zimmerman, A. Davison, B. L. Holman, B. K. Madras, J. Med. Chem., 40, 1835-1844, 1997.
  • "2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: Potent Non-Nitrogen Inhibitors of Monoamine Transporters", P. C. Meltzer, A. Y. Liang, P. Blundell, M. D. Gonzalez, Z. Chen, C. George, and B. K. Madras, J. Med. Chem., 40, 2661-2673, 1997
  • " A Ring Opening Rearrangement Reaction of 6b-Hydroxtropinone", Z. Chen, M. D. Gonzalez, P. Blundell, P. C. Meltzer, Tet. Lett., 38, 6823-6824, 1997.
  • "Altropane, a SPECT or PET Imaging Probe for Dopamine Neurons: I. Dopamine Transporter Binding in Primate Brain", B. K. Madras, P. C. Meltzer, A Y. Liang, D. R. Elmaleh, J. W. Babich, and A. J. Fischman, Synapse, 29, 93-104, 1998.
  • "Altropane, a SPECT or PET Imaging Probe for Dopamine Neurons: II. Distribution to Dopamine-Rich Regions of Primate Brain", B. K. Madras, L. M. Gracz, P. C. Meltzer, A Y. Liang, D. R. Elmaleh, M. J. Kaufman, and A. J. Fischman, Synapse, 29, 105-115, 1998.
  • "Altropane, a SPECT or PET Imaging Probe for Dopamine Neurons: III. Human Dopamine Transporter in Postmortem Normal and Parkinson's Diseased Brain", B. K. Madras, L. M. Gracz, M. A. Fahey, D. R. Elmaleh, P. C. Meltzer, A Y. Liang, E. G. Stopa, J. W. Babich, and A. J. Fischman, Synapse, 29, 116-127, 1998.
  • "Structure Activity Relationships of Inhibition of the Dopamine Transporter by 3-Arylbicyclo[3.2.1]octanes", P. C. Meltzer, P. Blundell, and B. K. Madras, Med. Chem. Res., 8, 12-34, 1998.
  • "Rapid detection of Parkinson’s disease by SPECT with altropane: a selective ligand for dopamine transporters", Fischman, A. J, Bonab, A. A, Babich, J. W, palmer, E. P, Alpert, N. M, Elmaleh, D. R, Callahan, R. J, barrow, S. A, Graham, W. Meltzer, P. C, Hanson, R. N, madras, B. K. Synapse, 29, 128-141, 1998.
  • "Bicyclo[3.2.1]octanes: Synthesis and Inhibition of Binding at the Dopamine and Serotonin Transporters", P. C. Meltzer, P. Blundell, Z. Chen, Y. Yong, and B. K. Madras, Bioorg. & Med. Chem. Lett., 9, 857-862, 1999.
  • "Non-amine dopamine transporter probe [3H]Tropoxene distributes to dopamine-rich regions in monkey brain", R. de la Garza. II, P. C. Meltzer, and B. K. Madras, Synapse, 34, 20-27, 1999.
  • "Point mutations of the human dopamine transporter (hDAT) reveal differential binding of an amine and a non-amine ligand", Soc Neurosci Abstra.25: 283, 1999Miller GM, Gracz LM, Goulet M, Yang H, Meltzer PC, Hoffman BJ, and Madras BK.
  • "Non-amines: a new generation of transporter drugs are potent serotonin reuptake blockers", Goulet M, Miller G. M, Meltzer P. C., Madras B. K. Soc Neurosci Abstra.25: 283, 1999
  • "[11C]Tropoxene: a dopamine transport inhibitor that bears no amine nitrogen, accumulates in the dopamine-rich striatum of monkey: a PET study", Madras B. K, Meltzer P. C, Bonab A. A, Livni, Babich J. W, Fischman A. J. J. Nucl. Med. 41: 208, 2000.
  • "3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes Inhibit WIN 35,428 Binding and Selectively at the Dopamine Transporter", P. C. Meltzer, P. Blundell, H. Huang, S. Liu, Y. F. Yong, and B. K. Madras, Bioorganic & Medicinal Chemistry, 8, 581-590, 2000.
  • "2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters", P. C. Meltzer, P. Blundell, Y. F. Yong, Z. Chen, C. George, M. D. Gonzalez, and B. K. Madras, J. Med. Chem., 43, 2982-2991, 2000.
  • "Molecular and regional targets of cocaine in primate brain: liberation from prosaic views. Addiction Biology", Madras B. K, Miller G. M., Meltzer P. C., Brownell A-L, Fischman A. J, Addiction Biology, 5, 351-359, 2000.
  • "Non-amines, drugs without an amine nitrogen, potently block serotonin transport (reuptake): novel anti-depressant candidates?", M. Goulet, G. M. Miller, P. C. Meltzer, B. K. Madras. Synapse, 42, 129-140, 2001.
  • "Association of psychostimulants on the dopamine transporter: Biochemical and molecular evidence for multiple binding domains", B. K. Madras, M. A. Fahey, P. C. Meltzer, G. M. Miller, Drug and Alcohol Dependence, 60, 383, 2000
  • "[(11)C, (127)I] Altropane: a highly selective ligand for PET imaging of dopamine transporter sites", Fischman, A. J, Bonab, A. A, Babich, J. W, Livni, E, Alpert, N. M. Meltzer, P. C, Madras, B. K. Synapse, 39, 332-342. 2001.
  • "A tropane horse I. Design and synthesis of a dopamine sparing antagonist", P. C. Meltzer, P. Blundell, S. Liu, H. Blanchette and B. K. Madras, Drug and Alcohol Dependence, 63, 414, 2001.
  • "A tropane horse II. O-1893 interferes with cocaine binding but permits dopamine transport: a cocaine antagonist strategy?" B. K. Madras, P. Blundell, S. Liu and P. C. Meltzer, Drug and Alcohol Dependence, 63, 378, 2001.
  • "Synthesis of 6- and 7-hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters", P. C. Meltzer, B. Wang, Z. Chen, P. Blundell, M. Jayaraman, M. D. Gonzalez, C. George, and B. K. Madras, J. Med. Chem., 44, 2619-2635, 2001.
  • "Monoamine transporters; novel insights with novel amines", B. K. Madras, G. M. Miller, A. J. Fischman, A. Bonab, and P. C. Meltzer, Naunyn-Schmiedeberg's Arch. Pharmacol. 358 (1), 35.181, 1998.
  • "A new 99m-technetium labeled ligand for SPECT imaging of dopamine transporte sites (O-1505T): preliminary evaluation in normal and MPTP treated monkeys", A. J. Fischman, P. Meltzer, S. Hillier, A. A. Bonab, R. J. Callahan, S. A. Barrow, and B. K. Madras, Soc. Nucl. Med. 40, 1161, 1999,
  • "Non-amines: A new generation of monoamine reuptake (dopamine, serotonin transporter) inhibitors". Soc. Neurosci. Abstr. 24, 278, 1998.
  • "Point mutations of the human dopamine transporter (hDAT) reveal differential binding of an amine and a non-amine ligand". G. M. Miller, L. M. Gracz, M. Goulet, H. Yang, P. C. Meltzer, B. J. Hoffman, and B. K. Madras. Soc. Neurosci. Abstr. 25, 283, 1999.
  • "Evaluation of a new and highly selective 99mTc labeled ligand for SPECT of dopamine transporter (DAT) sites". A. J. Fischman, P. C. Meltzer, S. Hillier, S. A Barrow, R. J. Callahan, A. A. Bonab, and B. K. Madras. Eur. J. Nucl. Med. 26, OS87, 1999.
  • "Association of psychostimulants on the dopamine transporter: biochemical and molecular evidence for multiple binding domains". B. K. Madras, M. A. Fahey, P. C. Meltzer, and G. M. Miller. Drug and Alcohol Dependence", 60, S135, 2000.
  • "Quantification of SPECT imaging with a highly selective DAT ligand 99mTc-O-1505". A. A. Bonab, P. C. Meltzer, S. Hillier, M. Burker, S. A. Barrow, B. K. Madras, and A. J. Fischman. J. Nucl. Med. 41, 185, 2000.
  • "Radiolabeling of the highly selective DAT ligand, Tc-O-1505, with 99mTc. Choice of transchelation agent". S. Hillier, M. Burker, P. C. Meltzer, B. K. Madras, and A. J. Fischman. J. Nucl. Med. 41, 185, 2000.
  • "Human DAT binding measurement with 11C-altropane", A. A. Bonab, N. M. Alpert, E. Livni, P. C. Meltzer, B. K. Madras, and A. J. Fischman. J. Nucl. Med. 42, 184, 2001.
  • "Human brain SPECT imaging with a highly selective DAT ligand 99mTc-O-1505T". A. A. Bonab, P. C. Meltzer, N. M. Alpert, M. Burker, S. D. Dragotakes, B. Barrow, B. K. Madras, and A. J. Fischman. J. Nucl. Med. 42, 210, 2001.
  • "Occupancy of the dopamine transporter by a transporter inhibitor, as measured by PET imaging, is predictive of therapeutic efficacy for Parkinsonism". B. K. Madras, P. C. Meltzer, J. W. Babich, A. A. Bonab, and A. J. Fischman. J. Nucl. Med. 42, 210, 2001.
  • "Dopamine transporter occupancy by candidate cocaine medications". B. K. Madras, P. C. Meltzer, A. A. Bonab, E. Livni, and A. J. Fischman. J. Nucl. Med. 43, 232, 2002.
  • "Evaluation of dopamine transporter (DAT) density in patients with Parkinson's disease (PD) by PET with 127I, 11C altropane". A. J. Fischman, A. A. Bonab, E. Livni, P. C. Meltzer, S. A. Barrow, and B. K. Madras,. J. Nucl. Med. 43, 18, 2002.
  • "The Tropane Horse: A novel cocaine antagonist strategy?" B. K. Madras, J. T. Bendor, A. R. Meyerhoff, G. M. Miller, and P. C. Meltzer. Drug and Alcohol Dependence", 60, S109:406, 2002.
  • "Non-amines: A generalization to methylphenidate and indatraline". P. C. Meltzer, P. Blundell, and B. K. Madras, Drug and Alcohol Dependence", 60, S118:441, 2002.
  • "The therapeutic potential of a dopamine transporter (DAT) inhibitor for Parkinson's disease: Comparison with AD2 dopamine agonist in MPTP-treated monkeys". B. K. Madras, P. C. Meltzer, and M. Goulet. Soc. Neurosc., in press.
  • " Design and synthesis of an irreversible dopamine-sparing cocaine antagonist" P. C. Meltzer, S. Liu, H. S. Blanchette, P. Blundell, and B. K. Madras. Bioorg. & Med. Chem. 10, 3583, 2002.
  • "Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate". P. C. Meltzer, P. Wang, P. Blundell, and B. K. Madras. J. Med. Chem. 46, 1538, 2003.
  • "A Second Generation 99mTechnetium SPECT Agent That Provides In Vivo Images of the Dopamine Transporter in Primate Brain" P. C. Meltzer, P. Blundell, T. Zona, L. Yang, H. Huang, A. A. Bonab, E. Livni, A. Fischman and B. K. Madras. J. Med. Chem. 46, 3483, 2003.
  • "Synthesis and Biological Activity of 2-Carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes" P. C. Meltzer, M. McPhee  and B. K. Madras, Bioorg. & Med. Chem. Lett. 13, 4133-4137, 2003.
  • "Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors" B. K. Madras, M. A. Fahey, G. M. Miller, R. DeLa Garza, M. Goulet, R. D. Spealman, P. C. Meltzer, S. R. George, B. F. O'Dowd, A. A. Bonab, E. Livni, A. J. Fischman, Eur. Journal Pharm. 479, 41-51, 2003.
  • "DAT Imaging: From Speculative to Spectacular", P. C. Meltzer, and B. K. Madras, NIDA Monog. 184, 76-79, 2004.
  • "Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters”, P. C. Meltzer, D-P. Pham-Huu, and B. K. Madras Bioorg. & Med. Chem. Lett. 14, 6007-6010, 2004.
  • "A new class of potent inhibitors of monoamine transport: 8-thiabicyclo[3.2.1]oct-2-enes", P. C. Meltzer, P. Pham-Huu, and B. K. Madras, College on Problems of Drug Dependence, Puerto Rico, 2004.
  • "The search for cocaine pharmacotherapies continues: Analogs of pyrrolidinyltolylpentanone (pyrovalerone) are potent inhibitors of monoamine transport", P. C. Meltzer, D. Butler, J. R. Deschamps and B. K. Madras, College on Problems of Drug Dependence, Florida, 2005.
  • "Synthesis of 3-(4-Heteroaryl-phenyl)-8-oxabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Esters" L. Torun, S. Liu, B. K. Madras and P. Meltzer, Tet. Lett. 47, 599-603, 2006.
  • "1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogs. A promising class of monoamine uptake inhibitors" P. C. Meltzer, D. Butler, J. R. Deschamps and B. K. Madras, J. Med. Chem. 49, 1420-1432, 2006.
  • "Dopamine transporter (DAT) inhibitors alleviate specific Parkinsonian deficits in monkeys: Association with DAT occupancy in vivo" B. K. Madras, M. A Fahey, M. Goulet, Z. Lin, J. Bendor, C. Goodrich, P. C. Meltzer, D. R Elmaleh, E. Livni, A.A Bonab, A. J. Fischman, J. Pharm. Exp. Ther.  319, 570-585, 2006.
  • "Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters”, D-P. Pham-Huu, J. R. Deschamps, S. Liu, B. K. Madras and P. C. Meltzer, Bioorg. & Med. Chem. 15, 1067-1082, 2007.
  • "Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using Altropane" T. J. Spencer, J. Biederman, B. K. Madras, A. A. Bonab, E. Livni, P. C. Meltzer, J. Martin, S. Rauch, A.J. Fischman, Biol. Psychiatry, 62, 1059-1061, 2007.
  • "The synthesis of bivalent 2β-carbomethoxy-3β-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters", P. C. Meltzer, O. Kryatova, D-P. Pham-Huu, P. Donovan, A. Janowsky.Bioorg. & Med. Chem.,16, 1832-1841 2008.
  • "The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes", Purushotham, M, Sheri, A., Pham-Huu, D-P, Madras, B. K., Janowsky, A, Meltzer, P.C.. Bioorg. & Med. Chem. Lett., 21, 48, 2011.

Chapter

"Non-Nitrogen-Containing Dopamine Transporter-Uptake Inhibitors", P.C. Meltzer in "Dopamine Transporters: ," M.L. Trudell & S. Izenwasser, eds., Wiley-VCH Verlag, 2009

Patents

  • "An Improved Process for Making 6-Desoxy-6-methylene-naloxone and 6-Desoxy-6-methylenenaltrexone," P. C. Meltzer and J.W. Coe, USP 4,535,157.
  • "Buspirone as a systemic immunosuppressan", R. Sharpe, S. J. Galli, K. A. Arndt, P. C. Meltzer, R. K. Razdan, and H. P. Sard, USP 5,484,788.
  • "Substituted 2-Carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl)nortropanes and their use as Imaging Agents for Neurodegenerative Disorders", D. R. Elmaleh, B. K. Madras, P.C. Meltzer, and R. N. Hanson, E. Pat. EP 0734385, 2002; USP 5,493,026, 1996.
  • "Cocaine Analogues and their use as Cocaine Substitutes, Cocaine Receptor Imaging Agents, and Imaging Agents for Neurodegenerative Disorders", B. K. Madras and P. C. Meltzer, USP 5,506,359, 1996.
  • "Use of Spiperone Derivatives as Immunosuppressant Agents", R. Sharpe, S. J. Galli, K. A. Arndt, P. C. Meltzer, R. K. Razdan, and H. P. Sard, USP 5,574,041.
  • "Use of spiperone or spiperone derivatives as immunosuppressant agents". R. Sharpe, S. J. Galli, K. A. Arndt, P. C. Meltzer, R. K. Razdan, and H. P. Sard, USP 5,693,645.
  • "Topical application of spiperone or derivatives thereof fro trewatment of pathological consitions associated with immune responses", R. Sharpe, S. J. Galli, K. A. Arndt, P. C. Meltzer, R. K. Razdan, and H. P. Sard, USP 5,703,088.
  • "Bridge-substituted tropanes for Methods of Imaging and Therapy", B. K. Madras and P. C. Meltzer, USP 5,770,180.
  • "Substituted 2-Carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl)nortropanes and their use as Imaging Agents for Neurodegenerative Disorders", D. R. Elmaleh, B. K. Madras, P.C. Meltzer, and R. N. Hanson, USP 5,853,696.
  • "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, B. K. Madras, P. Blundell, Z. Chen, USP 5,948,933.
  • "Dopamine Transporter Imaging Agent", P. C. Meltzer, B. K. Madras, A. G. Jones, A. Mahmood, A. Davison, P. Blundell, USP 6,171,576.
  • "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, B. K. Madras, P. Blundell, Z. Chen, USP 6,353,105.
  • "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, B. K. Madras, P. Blundell, Z. Chen, US Patent 6,417,221.
  • "Compounds with High Monoamine Transporter Affinity", P. C. Meltzer, B. K. Madras, P. Blundell, P. Wang, USP 6,525,206.
  • "Dopamine Transporter Imaging Agent", P. C. Meltzer, P. Blundell, B. K. Madras, A. J. Fischman, A.G. Jones, Mahmood, A. USP 6,548,041.
  • "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, B. K. Madras, P. Blundell, Chen, Zhengming, USP 6,670,375.
  • "Serotonin Transport Inhibitors", B. K. Madras, P. C. Meltzer, USP 6,677,338.
  • "Compounds with High Monoamine Transporter Affinity", P. C. Meltzer, B. K. Madras, P. Blundell, P. Wang, USP 7,026,516.
  • "Methods for Diagnosing and Monitoring Treatment for ADHD by Assessing the Dopamine Transporter Level", B. K. Madras, A. J. Fischman, P. C. Meltzer, USP 7,081,238.
  • "Boat Tropanes", P. C. Meltzer, P. Blundell, B. K. Madras, USP 7,105,678.
  • "Tropane Analogs and Methods for Inhibition of Monoamine Transport", P. C. Meltzer, B. K. Madras, P. Blundell, USP 7,199,132.
  • "Therapeutic Tropane Compounds", P. C. Meltzer, B. K. Madras, P. Blundell, S. Liu USP 7,439,264.
  • "Tropane Compounds", P. Blundell, P. C. Meltzer, B. K. Madras, USP 7,476,740.
  • "Compounds for modulating TRPV3 function", J. A. Chong, C. Fanger, G.R. Larsen, W.C. Lumma, M.M.Moran, A. Ripka, D. Underwood, M. Weigele, X. Zhen, A. Mahadevan, P. C. Meltzer USP 7,803790

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