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Howard P. Sard
Vice President of Organix Inc.

BIOGRAPHICAL SKETCH
EDUCATION

Institution Degree Year Conferred Field of Study
       
Tufts University, Medford MA B.S (Hons) 1978 Chemistry, Russian
Massachusetts Institute of Technology Ph.D. 1982 Organic Chemistry
Sisa Institute for Research Post-doc 1982 - 83 Organic Chemistry

Research and Professional Experience

1977 - 1978 Undergraduate Research, Tufts University, Medford MA.
1978 - 1979 Teaching Assistant, Massachusetts Institute of Technology, Cambridge MA.
1979 - 1982 Graduate Research, Massachusetts Institute of Technology, Cambridge MA.
1982 - 1983

Research Associate, The SISA Institute for Research, Cambridge, MA.

1983 - 1986 SISA Inc., Cambridge, MA.: Group Leader in Chemistry.
1986 - Co-founder, Vice-President and member of the Board of Directors of Organix Inc., a Massachusetts Research and Development Company,

Professional Activities

1978 -  Member, American Chemical Society.

Publications

  • "(Trimethylsilyl)vinylketene, a stable vinylketene and reactive enophile in 4+2 cycloadditions," R. Danheiser and H. Sard, J. Org. Chem., 45, 4810, 1980.
  • "Cyclohexenol annulation via the alkoxy-accelerated rearrangement of vinylcyclobutanes," R. Danheiser, C. Martinez-Davila and H. Sard, Tetrahedron, 37, 3943, 1981.
  • "A 4+4 annulation approach to eight-membered carbocyclic compounds," R. Danheiser, S. Gee and H. Sard, J. Am. Chem. Soc., 104, 7670, 1982.
  • "The regiochemical course of 2+2 cycloadditions of dichloroketene with vinyl- and alkynylsilanes," R. Danheiser and H. Sard, Tet. Letters, 23, 1983.
  • "A novel route to 1-(N,N-dimethylamino)-2-butanol," H. Sard, R. Duffley and R. Razdan, Syn. Comm.,13, 813, 1983.
  • "Improved procedure for the preparation of chiral 1,2-epoxybutanes: Total Synthesis of (S)-3'-hydroxy-Δ9-tetrahydrocannabinol (THC), a highly active metabolite of ?9-THC", H. Sard, R. Duffley, L. Robertson, and R. Razdan, Synthesis, 506, 1984.
  • "The reaction between an azomethine and malonyl dichloride," H. Sard, P. Meltzer and R. Razdan, J. Het. Chem. 22, 257, 1985.
  • "Ring closure of thiosemicarbazides with sulfuric acid-A structure correction," H. Sard, P. Meltzer and R. Razdan, J. Het. Chem., 22, 361, 1985.
  • "Synthesis and Pharmacological Evaluation of Mercapto and Thioacetyl Analogs of Cannabidiol and Δ8-Tetrahydrocannabinol," D. Compton, P. Little, B. Martin, J. Saha, J. Gilman, H. Sard, and R. Razdan, Eur. J. Med. Chem., 24, 293, 1989.
  • "Synthesis and Pharmacological Evaluation of Amino, Azido, and Nitrogen Mustard Analogues of 10-Substituted Cannabidiol and 11- or 12-Substituted Δ8-      Tetrahydrocannabinol," D. Compton, P. Little, B. Martin, J. Saha, J. Gilman, V. Jorapur, H. Sard, and R. Razdan, J. Med. Chem., 33, 1437, 1990.
  • "An Unexpected Product During Synthesis of 3-Phenylisoquinoline: Improved Preparation of 4-Hydroxy-3-phenylisoquinoline" H. Sard, J. Het. Chem. 31, 1085, 1994.
  • "Synthesis and Antiviral Activity of the Cyclopropano Homolog of 2,3-Didehydro-     2,3-dideoxythymidine" H. Sard, Nucleosides and Nucleotides 13, 2321, 1994.
  • "The Synthesis and Pharmacological Evaluation of the Cannabinoid Antagonist SR 141716" A. Dutta, H. Sard, W. Ryan, R. Razdan, D. Compton, and B. Martin, Med. Chem. Res. 5, 54, 1994.
  • "Cyclization of 3-Fluorophenol and 3,3-Dimethylacrylic acid: A Structure Correction" F. Shawcross and H. Sard J. Het. Chem., 32, 1393, 1995.
  • "Preparation of 4,5-Disubstituted Pyrimidines: Ring Substitution of 5-Mesyloxymethylpyrimidines" H. Sard, M. Gonzalez, A. Mahdevan, and J. McKew J. Org. Chem. 65, 9261, 2000.
  • "A General Method for C3 Reductive Alkylation of Indoles" A.Mahadevan, H. Sard, M. Gonzalez, and J. McKew Tetrahedron Letters 44, 4589, 2003. 
  • “SAR of Psilocybin Analogs: Discovery of a Selective 5-HT2C Agonist” H. Sard, G. Kumaran, C. Morency, B. Roth, B. Toth, P. He, and L. Shuster Bioorg. Med. Chem. Lett. 15, 4555, 2005.
  • “Inhibition of Cytosolic Phospholipase A2a: Hit to Lead Optimization” J. McKew, M. Foley, P. Thakker, M. Behnke, F. Lovering, F.-W. Sum, S. Tam, K. Wu, M. Shen, W. Zhang, M. Gonzalez, S. Liu, A. Mahadevan, H. Sard, S. Khor, J. Clark J. Med. Chem. 49, 135, 2006.

Books

1. Contributor to "Encyclopedia of Reagents for Organic Synthesis", L. Paquette, Editor, John Wiley and Sons, Ltd., Sussex, UK, 1995.

Patents

  • "Use of Spiperone Derivatives as Immunosuppressant Agents," R. Sharpe, K. Arndt, S. Galli, P. Meltzer, R. Razdan, and H. Sard, U. S. Patent No. 5,574,041 (1996).
  • "Buspirone as a Systemic Immunosuppressant," R. Sharpe, K. Arndt, S. Galli, P. Meltzer, R. Razdan, and H. Sard, U. S. Patent No. 5,484,788 (1996).
  • "Use of Spiperone or Spiperone Derivatives as Immunosuppressant Agents," R. Sharpe, K. Arndt, S. Galli, P. Meltzer, R. Razdan, and H. Sard, U. S. Patent No. 5,693,645 (1997).
  • "Topical Application of Spiperone or Derivatives Thereof forTreatment of Pathological Conditions Associated with Immune Responses" R. Sharpe, K. Arndt, S. Galli, P. Meltzer, R. Razdan, and  H. Sard, U. S. Patent No. 5,703,088 (1997).
  • "Indole Compounds Useful as Serotonin Selective Agents" H. Sard, L. Shuster, B. Roth, C. Morency, G. Kumaran, L. Xu, U.S. 7,655,691, issued February 2, 2010.
  • "Indole Compounds and Methods of Use Thereof" H. Sard, Y. Zhang, J. Li, L. Shuster, B. Roth, U.S. Patent Application No. 61/027825; filed February 11, 2008.

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