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Anu Mahadevan
Vice President of Organix Inc.

BIOGRAPHICAL SKETCH
EDUCATION

Institution Degree Year Conferred Field of Study
       
University of Madras BSc 1987 Chemistry
IIT, Madras MSc 1989 Chemistry
Purdue University Ph.D. 1994 Organic Chemistry
Florida State University Post-doc 1996 Organic Chemistry

Research and Professional Experience

1997 - 2001 Research Scientist, Research Associate, Organix, Inc.
2002 - 2004 Group Leader, Organix, Inc.
2005 - Vice-President and member of the Board of Directors of Organix Inc., a Massachusetts Research and Development Company

Awards

University Medal; BSc

Merit Scholarship; MS (1987 – 1989)

Mobil Fellowship (summer 1990)

Publications

  • "A Mild and Convenient Synthesis of Functionalized Methyl Triflones and Vinyl Triflones", A. Mahadevan, P. L. Fuchs, Tetrahedron Lett. 1994, 35, 6025.
  • "Silver Fluoroborate-Promoted Sulfur Alkylation of b-Thioglycosides", A. Mahadevan, C. Li, P. L. Fuchs, Synth. Commun. 1994, 24(21), 3099.
  • "Synthesis and Pharmacological Evaluation of Vinyl Sulfone Based Anticancer Drugs", C. Li, A. Mahadevan, A. Arasappan, J. Philips, R. Merriman, L. Tanzer, P. L. Fuchs, Bioorg. Med. Chem. Lett. 1994, 4, 1585.
  • "Facile Synthesis of Allyl, g-Iodoallyl, and Cyclopropyl Triflones via Radical-Mediated Atom-Transfer Addition of Iodomethyl Triflone to Olefins and Acetylenes", A. Mahadevan, P. L. Fuchs, J. Am. Chem. Soc. 1995, 117, 3272.
  • "Stereo- and Regiospecific Syntheses of a- and b-Substituted Vinyl and Dienyl Triflones via the Stille Reaction", J. S. Xiang, A. Mahadevan, P. L. Fuchs, J. Am. Chem. Soc. 1996, 118, 4284.
  • "Novel Cannabinol Probes for CB1 and CB2 Cannabinoid Receptors", A. Mahadevan, C. Siegel, B. R. Martin, M. E. Abood, I. Beletskaya, R. K. Razdan, J. Med. Chem. 2000, 43, 3778.
  • "Cannabinoid Properties of Methylfluorophosphonate Analogs", B. R. Martin, I. Beletskaya, G. Patrick, R. Jefferson, R. Winckler, D. Deutsch, V. DiMarzo, O. Dasse, A. Mahadevan, R. K. Razdan, J. Pharmacol. Exp. Ther. 2000, 294, 1209.
  • "The Synthesis of N-Vinillyl-arachidonyl-amide (Arvanil) and its Analogs: An Improved Procedure for the Synthesis of the key Synthon Methyl 14-hydroxy-(all-cis)-5,8,11-Tetradecatrienoate", O. Dasse, A. Mahadevan, L. Han, B. R. Martin, V. DiMarzo, R. K. Razdan, Tetrahedron 2000, 56, 9195.
  • "Preparation of 4,5-Disubstituted Pyrimidines: Ring Substitution of 5-Mesyloxymethylpyrimidines", H. Sard, M. D. Gonzalez, A. Mahadevan, J. McKew, J. Org. Chem. 2000, 65, 9261.
  • "Novel Pyrazole Cannabinoids: Insights into CB1 Receptor Recognition and Activation", J. L. Wiley, R. G. Jefferson, M. C. Grier, A. Mahadevan, R. K. Razdan, B. R. Martin, J. Pharmacol. Exper. Ther. 2001, 296, 1013.
  • "Highly Selective CB1 Cannabinoid Receptor Ligands and Novel CB1/VR1 Vanilloid Receptor “Hybrid” Ligands," V. DiMarzo, T. Bisogno, L. De Petocellis, I. Brandi, R. L. Jefferson, R. L. Winckler, J. B. Davis, O. Dasse, A. Mahadevan, R. K. Razdan, B. R. Martin, Biochem. Biophys. Res. Commun. 2001, 281, 444.
  • "A Structure Activity Relationship Study on Arvanil, an Endocannabinoid and Vanilloid Hybrid", V. DiMarzo, G. Griffin, L. De Petrocellis, I. Brandi, T. Bisogno, W. Williams, M. C. Grier, S. Kulasegram, A. Mahadevan, J. B. Davis, R. K. Razdan, B. R. Martin, J. Pharmacol. Exper. Ther. 2002, 300, 984.
  • "Resorcinol Derivatives: A Novel Template for the Development of Cannabinoid CB1/CB2 and CB2-Selective Agonists", J. L. Wiley, I. D. Beletskaya, E. W. Ng, D. Zongmin, P. J. Crocker, A. Mahadevan, R. K. Razdan, B. R. Martin, J. Pharmacol. Exper. Ther. 2002, 301, 679.
  • "Recent Advances in the Synthesis of Endocannabinoid Related Ligands", R. K. Razdan, A. Mahadevan, Chem. Phys. Lipids 2002, 121/1-2, 21.
  • "SR-141716A Induced Stimulation of Locomotor Activity; A Structure-Activity Relationship Study", C. E. Bass, G. Griffin, M. Grier, A. Mahadevan, R. K. Razdan, B. R. Martin, Pharmacol. Biochem. Behav. 2002, 74, 31-40.
  • "A General Method for C3 Reductive Alkylation of Indoles", A. Mahadevan, H. Sard, M. Gonzalez, J. C. McKew, Tetrahedron Lett. 2003, 44, 4589.
  • "A Novel Methodology for the Synthesis of 1-desoxy-Δ8-tetrahydrocannabinol (THC) analogues", H. Sun, A. Mahadevan, R. K. Razdan, Tetrahedron Lett. 2004, 45, 615.
  • "6”-Azidohex-2”-yne-cannabidiol: A Potent Neutral, Competitive Cannabinoid CB1 Receptor Antagonist", A. Thomas, R. A. Ross, B. Saha, A. Mahadevan, R. K. Razdan, R. G. Pertwee, Eur. J. Pharmacol. 2004, 487, 213.
  • "A Comparison of the Discriminative Stimulus Effects Δ9-Tetrahydrocannabinol and O-1812, a Potent and Metabolically Stable Anandamide Analog, in Rats", J. L. Wiley, K. L. LaVecchia, N. E. Karp, S. Kulasegaram, A. Mahadevan, R. K. Razdan, B. R. Martin, Experimental and Clinical Psychopharmacology 2004, 12, 173.
  • "A Synthetic Route to Anandamide Analogues Carrying a Substituent at the Terminal      Carbon and an Acetylene Group in the End Pentyl Chain", R. Altundas, A. Mahadevan, R. K. Razdan, Tetrahedron Lett. 2004, 45, 5449.
  • "Inhibition of Monoacylglycerol Lipase and Fatty Acid Amide Hydrolase by Analogues of 2-Arachidonylglycerol", N. Ghafouri, G. Tiger, R. K. Razdan, A. Mahadevan, R. G. Pertwee, B. R. Martin, C. J. Fowler, Br. J. Pharmacol., 2004, 143,774.
  • "Synthesis of novel 5-substituted pyrazole derivatives as cannabinoid antagonists", O. Alekseeva, A. Mahadevan, J. L. Wiley, B. R. Martin, R. K. Razdan, Tetrahedron Lett. 2005, 46, 2159.
  • "CB1 Cannabinoid Receptor-Mediated modulation of Food Intake in Mice", J. L. Wiley, J. J. Burston, D. C. Leggett, R. K. Razdan, A. Mahadevan, B. R. Martin, Br. J. Pharmacol. 2005, 145, 293.
  • "Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonylglycerol with monoglycerol lipase and fatty acid amide hydrolase", S. Vandevoorde, B. Saha, A. Mahadevan, R. K. Razdan, R. G. Pertwee, B. R. Martin, C. J. Fowler, Biochem. Biophys. Res. Commun. 2005, 337, 104.
  • "Further Advances in the Synthesis of Endocannabinoid-related Ligands", A. Mahadevan, R. K. Razdan, AAPS 2005, 07(02), E496.
  • "New Potent and Selective Inhibitors of Anandamide Re-Uptake with Anti-Spastic Activity in a Mouse Model of Multiple Sclerosis", A. Ligresti, M. G. Cascio, G. Pryce, S. Kulasegaram, I. Beletskaya, L. De Petrocellis, B. Saha, A. Mahadevan, C. Visintin, J. L. Wiley, D. Baker, B. R. Martin, R. K. Razdan, V. Di Marzo, Br. J. Pharmacol., 2006, 147,83.
  • "Inhibition of Cytosolic Phospholipase A2a: Hit to Lead Optimization", J. C.  McKew, M. A. Foley, P. Thakker, M. L. Behnke, F. E. Lovering, F-W. Sum, S. Tam, K. Wu, M. W. H. Shen, W. Zhang, M. Gonzalez, S. Liu, A. Mahadevan, H. Sard, J. Med. Chem. 2006, 49, 135.
  • " Development of the first potent and specific inhibitors of endocannabinoid biosynthesis",  T. Bisogno, M. G. Cascio, B. Saha, A. Mahadevan, P. Urbani, A. Minassi, G. Appendino,  C. Saturnino, B. R. Martin, R. K. Razdan, V. Di Marzo, Biochim. Biophys. Acta.  2006, 1761, 205–212.
  • "Novel compounds that interact with both Leukotiene B4 receptors and vanilloid TRPV1 receptors", D. McHugh, R. S. McMaster, R. G. Pertwee, S. Roy, A. Mahadevan, R. K. Razdan, R. A. Ross, J. Pharmacol. Exper. Ther. 2006, 316, 955.
  • "Pharmacological Characterization of Novel Water-Soluble Cannabinoids", B. R. Martin, J. L. Wiley, I. Beletskaya, L. J. Sim-Selley, F. L. Smith, W. L. Dewey, Cottney, J.; Adams, J.; Baker, J.; Hill, D.; Saha, B.; Zerkowski, J.; Mahadevan, A.; R. K. Razdan, J. Pharmacol. Exper. Ther. 2006, 318, 1230-1239.
  • "The role of fluorine substitution in the structure-activity relationships (SAR) of classical cannabinoids", P. J. Crocker, A. Mahadevan, J. L. Wiley, B. R. Martin, R. K. Razdan, Bioorg. Med. Chem. Lett. 2007, 17, 1504-1507. PMC 1855243.
  • "Novel, potent THC/anandamide (hybrid) analogs", C. Bourne, S. Roy, J. L. Wiley,  B. R. Martin, B. F. Thomas, A. Mahadevan, R. K. Razdan, Bioorg. Med. Chem.  2007, 15, 7850-7864. PMC 2112747.
  • "Multiple pathways involved in the biosynthesis of anandamide", J. Liu, L. Wang, J. Harvey-White, B. X. Huang, H. Y. Kim, S. Luquet, R. D. Palmiter, G. Krystal, R. Rai, A. Mahadevan, R. K. Razdan, G. Kunos, Neuropharmacology.  2008, 54, 1, 1-7. PMC 2219543.
  • " Synthesis of 2-(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamidoethyl-d4 dihydrogen phosphate, tetra-deuterated pAEA", K. Cheng, B. Saha, A. Mahadevan, R. K. Razdan, G. Kunos, A. E. Jacobson, K. C. Rice, J. Label Compd. Radiopharm 2008, 51, 389-390.  
  • "N-Arachidonyl maleimide (NAM) potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase", J. J. Burston, L. J. Sim-Selley, J. P. Harloe, A. Mahadevan, R. K. Razdan, D. E. Selley, J. L. Wiley, J Pharmacol Exp Ther, 2008, 327: 546-553.  PMID 18682568.
  • "Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonylglycerol", T. Bisogno, J. J. Burston, R. Rai, M. Allara, B. Saha, A. Mahadevan, R. K. Razdan, J. L. Wiley, V. Di Marzo, ChemMedChem, 2009, 4: 946-50.  PMID 19266526.
  • "Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception", L. Booker, P. S. Naidu, R. K. Razdan, A. Mahadevan, A. H. Lichtman, Drug Alcohol Depend. 2009, 105(1-2); 42-47.  PMID 19679411.
  • "The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects", S. G. Kinsey, A. Mahadevan, B. Zhao, H. Sun, P. S. Naidu, R. K. Razdan, D. E. Selley, M. Imad Damaj, A. H. Lichtman, Neuropharmacology 2011, 60, 244-251.  PMID 20849866.
  • " Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB1 receptor antagonist", J. L.Wiley, C. S. Breivogel, A.Mahadevan, R. G. Pertwee, M. G. Cascio, D. Bolognini, J. W. Huffman, M. D. Walentiny, R. E. Vann, R. K. Razdan, B. R. Martin, Eur. J. Pharmacol. 2011, 651, 96-105.

Patents

  • "Pyrazole Cannabinoid Agonist and Antagonist", B. R. Martin, R. K. Razdan, A. Mahadevan, USP 6,509,367.
  • "Anti-spasticity of an eicosanoid analog", B. R. Martin, R. K. Razdan, A. Mahadevan, D. Baker, USP 6,800,770.
  • "Water soluble cannabinoids", B. R. Martin, R. K. Razdan, A. Mahadevan, WO 2006/012176.
  • "Compounds for modulating TRPV3 function", J. A. Chong, C. Fanger, G. R. Larsen, W. C. Lumma, A. Mahadevan, P. Meltzer, M. M. Moran, A. Ripka, D. J. Underwood, M. Weigele, X. Zhen, WO 2008/060626.
  • "Inflammation Therapy", B. R. Martin, M. I. Damaj, M. W. Adler, R. F. Tuma, M. Zhang, A. Mahadevan, R. K. Razdan, US 2008/0139635.
  • "Compounds for modulating TRPV3 function", J. A. Chong, C. Fanger, G. R. Larsen, W. C. Lumma, A. Mahadevan, P. Meltzer, M. M. Moran, A. Ripka, D. J. Underwood, M. Weigele, X. Zhen, US 2010/0152209.

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